Flight José Marti International Airport departs from Havana José Marti International Airport at 05:20 and arrives at Panama City Tocumen International Airport at 08:08.
The flighttime is about 3h 48m. The distance travelled ("as the bird flies"): 414 Km. So the average speed is roughly 109 Km.
There is an 1 hour time difference between Havana and Panama City