Flight International Airport departs from San Francisco International Airport at 00:45 and arrives at Panama City Tocumen International Airport at 14:45.The flight has a short stop at Houston.
The flighttime is about 12h 00m. The distance travelled ("as the bird flies"): 4667 Km. So the average speed is roughly 389 Km.
There is an 2 hour time difference between San Francisco and Panama City